Two-step aberration correction: application to transcranial histotripsy
Published in Physics in Medicine & Biology, 2022
Abstract: Phase aberration correction (AC) is crucial in transcranial histotripsy to correct for the skull-induced focal distortion. This paper enhances a 2-step AC method for clinical use, combining a CT-based analytical approach with a cavitation-based approach using acoustic cavitation emission (ACE). A 700 kHz, 360-element hemispherical transducer was used to generate histotripsy-induced cavitation and acquire ACE shockwaves. Testing on excised human skulls showed that the 2-step AC achieved 90 ± 7% peak focal pressure, reduced focal shift, and improved refocusing compared to individual AC methods. This real-time AC workflow enhances transcranial histotripsy for brain therapy.
Recommended citation: N. Lu, et al. (2022). "Two-step aberration correction: application to transcranial histotripsy." Physics in Medicine & Biology. 67(12).
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