Research Portfolio

High-Level Summary

My research aims to transform ultrasound into a precision, affordable, and personalized platform for diagnosing and treating disease. I develop integrated technologies that combine high-resolution imaging, non-invasive therapy, and real-time monitoring and feedback, enabling systems that can see, decide, and treat with high accuracy. Motivated by urgent clinical needs, my work targets improving outcomes in diseases such as cancer, stroke, and neurodegeneration, where earlier detection and more precise, less invasive interventions can significantly improve survival and quality of life. Through close collaboration with clinicians, engineers, and industry partners, I strive to translate these innovations into practical tools that expand access to safe, effective, and personalized care.

Research Pillars

1. Precision Non-Invasive Therapy (Histotripsy and Beyond)

I develop next-generation ultrasound therapies that mechanically ablate diseased tissue without surgery, radiation, or heat. My work on transcranial histotripsy established key technologies for non-invasive brain treatment, with the broader vision of enabling safer and more effective therapies for cancer and neurological disorders.

2. Real-Time Volumetric Imaging

Ultrafast 3D imaging provides high-resolution, large–field-of-view visualization that supports dynamic monitoring of anatomy and therapy. This capability enhances precision in interventions across applications such as spine and breast imaging, enabling clinicians to make timely and informed decisions.

3. Intelligent Image-Guided Therapy with Real-Time Feedback

I develop technologies that allow clinicians to see and assess treatment effects in real time using acoustic signals and high-speed imaging. By providing direct visualization and quantitative feedback during therapy, this work enables more precise, safer, and more consistent interventions, particularly in complex and patient-specific settings.

4. Scalable Ultrasound Systems

Integrated system development—from custom hardware and large-scale arrays to high-performance computing and real-time algorithms—is essential for translating laboratory innovations into clinical practice. These scalable platforms ensure that advanced ultrasound technologies can be deployed safely and effectively in real-world healthcare settings.

5. Expanding Access and Clinical Impact

Affordable, portable, and high-precision ultrasound technologies have the potential to transform early diagnosis, intervention, and therapy. By working closely with clinical collaborators, I focus on solutions that address real-world needs and can impact diverse patient populations.

Useful Links